Published April 17, 2020
by Mike Sepanic
The fight against the coronavirus is underway in a Rutgers University–Camden research laboratory.
The fight against the coronavirus is underway in a Rutgers University–Camden research laboratory, where chemistry professor Jinglin Fu is working to develop a mechanism to rapidly detect viral RNA for potential diagnosis of COVID-19.
“The main problem that we want to address is an urgent need of a rapid and reliable assay that is simple and affordable for mass screening to prevent the spread of infectious diseases, such as the current COVID-19 pandemic,” explains Fu. “Right now, the diagnosis of COVID-19 is limited by the slow speed of traditional polymerase chain reaction and the inaccuracy of antibody test. Our goal is to accelerate that timetable.”
The nucleic acid assay can be simply adapted to detect specific DNA/RNA sequences of several diseases, including coronavirus and MRSA, and other transmitting infectious diseases active in the United States.
“The convenience of being quickly customizable and adaptable will be of value for mass screening and early intervention for future pandemics,” says Fu.
The new virus detection process under development at Rutgers University–Camden is based on the patented DNA Logic-gated Proximity Assembly Circuit technology that can directly detect viral-specific nucleic acid sequences, with a triggered biochemical reaction to produce fluorescence and colorimetric signal on a paper strip. According to the Rutgers–Camden researcher, the successful outcome of the research would handle various types of swabs (oral, throat, and nasal) and blood samples with a simple procedure and a rapid viral RNA read-out. The technology under development can lead to a diagnosis product for point-of-care use by health care providers to screen for emerging infectious diseases.
“This development is at the early stage,” explains Fu. “We are now testing the sensor accuracy for detecting RNA segments of COVID-19 viruses and have not yet detected real virus sample.”
Fu’s research lab focuses on developing regulatory biochemical reaction circuits that can be used to detect various molecular targets, such as nucleic acid, proteins, and small molecules. The Rutgers University–Camden lab invented a unique technique of DNA-mediate proximity assembly circuit (DPAC), which is a rapid nucleic acid detection system that reports a fluorescence or colorimetric signal for simple read-out.
DPAC uses a rationally designed nanostructured sensor to detect sequence-specific nucleic acids, such as microRNA, which are important biomarkers for cancer. The development of DPAC at Rutgers–Camden was sponsored by the U.S. Army Research Office for advancing smart biosensors for diagnosing and monitoring disease. Based on DPAC technology, Fu participated in NSF I-Corps in fall 2019 and performed more than 100 customer interviews with health professionals to understand the unmet need in disease diagnosis. The team is ready to apply the lab-developed technology to address the urgent need in infectious diseases diagnosis.
Situated in Camden’s Joint Health Sciences Center, the Rutgers University–Camden research lab includes the contributions of graduate and undergraduate students and is building on a patented technology that was selected for NSF I-Corps last fall. The coronavirus-related research continues with only one researcher in the lab at a time.
Conducted as part of the Center for Computational and Integrative Biology at Rutgers University–Camden, Fu’s research focuses on bio-mimetic materials and smart nanodevices capable of performing catalysis, computing and sensing for potential applications in biofuel production, diagnosis, and drug delivery.
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Rutgers in the News: Kamala Harris, Voting Controversies, and School Openings
Whether you’re looking for insight into U.S....
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Rutgers Researchers Awarded $20 Million NIH Grant to Find New Ways to Diagnose Tuberculosis
The research team of infectious disease experts...
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Early Antibiotic Use Increases Risk of Inflammatory Bowel Disease
A study, published in Genome Medicine, provides...
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Rutgers in the News: COVID-19 and the National Conversation on the Use of Power
Rutgers continues to serve as a model for...
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Greg and Anna Brown Commit $1 Million to Student Financial Aid
The gift from the Browns is the third...
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A Rutgers Giving Day Like No Other
Building on the momentum of previous years,...
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Alumni Gary and Barbara Rodkin Commit $1 Million to Student Financial Aid
The gift from Gary and Barbara Rodkin is the...
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Rutgers in the News: Educational Values, COVID-19, and the Economy
Rutgers continues to serve as a model for...
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Rutgers in the News: Social Justice and Navigating COVID
In these turbulent times, Rutgers continues to...
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Does Asthma Raise COVID Risks? New Rutgers Study Suggests No
Reynold A. Panettieri Jr., a pulmonary critical...
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Rutgers in the News: Addressing systemic injustice and opening schools in the face of COVID
News outlets turn to Rutgers faculty and...
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Rutgers Bacteria Study Could Lead to Better COVID Disinfection Methods
A new Rutgers study, published in the...
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Rutgers University Announces Fall 2020 Plans
The fall semester at Rutgers University will...
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Rutgers Board Chair Joins President Holloway’s Call to Action
Scarlet Promise Grants offer essential financial...
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Rutgers Experts on COVID Concerns, Equal Representation, and the Legacy of Racism
New Rutgers President Jonathan Holloway arrives...
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A message from Rutgers President Jonathan Holloway
Today, Jonathan Holloway, the 21st president of...
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Thank You For Your Support
Donors to Rutgers are exemplary. Many demonstrate...
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Rutgers Experts on Containing COVID-19 and Fighting for Equality
As the rise in COVID cases complicates the...
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Rutgers Experts on Black Inequality and Coronavirus Safety
Your weekly guide to Rutgers experts in the news....
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Rutgers to Support Statewide Contact Tracing Program
Rutgers University has partnered with the State...
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Rutgers Experts on Racial Justice, COVID Pandemic, and New Political Realities
Members of the Rutgers community have come...
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The Perfect Storm of Pandemics
Brian L. Strom, chancellor of Rutgers Biomedical...
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Rutgers Sociologist Awarded Fellowship Aimed at Eradicating Racial Disparities in the Arts and Humanities
Melissa Valle is one of 32 fellows chosen from...
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Rutgers Researchers Receive Award to Develop First-in-Class Anticancer Therapeutics
Rutgers cancer researchers have been awarded...
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Charitable Gift Annuity Rates
The charitable gift annuity (CGA) is a simple and...
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Rutgers’ Critical Role in Pandemic Recovery
As areas of the country slowly reopen under...
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As the Nation Slowly Reopens, Rutgers Helps Chart the Path
University experts have been at the forefront of...
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How Rutgers Leads at a Time of Crisis
Rutgers University presence at the front lines of...
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New RWJMS Study Finds Young People at Greater Risk From COVID-19 Than Previously Thought
Children, teens and young adults are at greater...
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Rutgers Community is Responding to COVID-19
During these unprecedented times, Rutgers...
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FDA Approves First At-Home Saliva Collection Test for Coronavirus
Rutgers’ RUCDR Infinite Biologics received an...
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Rutgers Leads Clinical Trial of Drug to Prevent Cytokine Storms in COVID-19 Patients
Rutgers has launched a clinical trial to test...
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Rutgers Community Raises over $250,000 on #GivingTuesdayNow
Alumni and donors raise more than $250,000 for...
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#GivingTuesdayNow: Join Rutgers in the Fight Against COVID-19
Join the global movement to fight COVID-19 today,...
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Rutgers Plays Key Role in Reopening New Jersey
Governor Phil Murphy's plan to safely rollback...
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Rutgers Law Mortgage Foreclosure Project Assists in Saving New Jersey Residents from Losing their Homes
A Rutgers University–Camden law professor and...
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Rutgers, University Hospital Lead Way in Treating COVID-19 with Convalescent Plasma from Recovered Patients
Rutgers physicians and University Hospital are...
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New Rutgers Saliva Test for Coronavirus Gets FDA Approval
The FDA has granted emergency use authorization...
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How the CARES Act Affects Charitable Giving
On March 27, in response to the economic strain...
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Message from President Barchi
Rutgers President Robert Barchi sends a message...
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Rutgers Launches Genetic Testing Service for New Coronavirus
Rutgers’ RUCDR Infinite Biologics has launched...
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What it Takes to Beat a Worldwide Pandemic
Rutgers Biomedical and Health Sciences (RBHS) has...
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Rutgers Creates COVID-19 Center to Fight Pandemic
Rutgers has created a new center to coordinate...
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New Device Quickly Detects Harmful Bacteria in Blood
Engineers have created a tiny device that can...
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How the Building Blocks of Life Got Built
Rutgers researchers have discovered the origins...
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Message to Alumni and Donors Regarding COVID-19 Response
Rutgers University Foundation president, Nevin...
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Supporting students during the COVID-19 outbreak
Many of you have asked how you can help students...
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Rutgers Recognized as a Leader in Supporting Low-Income Students
Rutgers University-New Brunswick is a national...
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Rutgers Leads $1.5 Million Project for Ocean Acidification Monitoring on the U.S. Northeast Shelf
Grace Saba, assistant professor, is the lead...
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Surgeon who Separated Conjoined Twins Mentors Rutgers Undergraduates
A Rutgers graduate, Stylianos led the teams that...
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Jonathan Holloway Named 21st President of Rutgers, The State University of New Jersey
Holloway will begin serving as president on July...
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Rutgers Giving Tuesday Initiative to End Student Hunger
Being a student is hard. It’s even harder when...
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Putting an End to a Pernicious Disease
Rutgers neuroscientists are exploring promising...
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Putting the Promise in Scarlet Promise Grants
In an effort to help more students avoid...
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Growing for the Greater Good
Through the generosity of donors such as Richard...
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Grand Opening Held for RWJBarnabas Health Athletic Performance Center at Rutgers University
Rutgers Athletics held a ribbon-cutting ceremony...
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Donor Profiles
Rutgers Alumnus Makes Largest Scholarship Gift Ever to University
Richard N. Weeks, a 1950 Rutgers graduate who...
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Rutgers’ Record-Breaking Fundraising Year Will Improve Lives in New Jersey and Beyond
Rutgers donors committed a record-breaking $250.9...
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Impact Stories
Rutgers Community Donates Paul Robeson Plaza
Rutgers is in the midst of celebrating 2019 as...
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Lavelle Fund Gift for Blindness Program
A grant from the Lavelle Fund for the Blind to...
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Donor Profiles
From Meter Reader to Multimillion-Dollar Donor: The Remarkable Journey of a SMLR Alumnus
Bill and Lois Dwyer are gifting $50,000 to...
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Impact Stories
Alumna Marlene Brandt commits $30 million to transform behavioral health care for young people
Spurred by a pressing need for comprehensive...
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Helping Tomorrow’s Leaders Meet Their Potential
Former Rutgers Assistance Grants get a boost with...
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Impact Stories
Prudential Establishes Newark Scholarship Program
Rutgers University–Newark received welcome news...
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The Demand for Special Needs Dentists
John Barnosky became an advocate for expanding...
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Rutgers Approves Construction of Athletic Practice Facility
The Rutgers University Board of Governors today...
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