Published April 21, 2021
The National Institutes of Health has awarded neuroscience professor Mark Gluck a grant to investigate the links between Alzheimer's Disease and COVID-19, which share common immunological pathways and age-related risks.
Mark Gluck, Professor of Neuroscience at the Center for Molecular & Behavioral Neuroscience (CMBN) at the School of Arts & Sciences-Newark, has received a new grant from the National Institutes of Health (NIH) to study the cognitive, neural, and immunological consequences of COVID-19 in older African Americans and how they relate to risk for Alzheimer’s Disease.
With this grant, Gluck seeks to investigate the links between Alzheimer’s Disease and COVID-19, which share common immunological pathways and age-related risk. This is particularly critical for African Americans since they are known be at elevated risk for age-related cognitive decline and Alzheimer’s Disease, and are also currently experiencing the highest overall COVID-19 mortality rates. Understanding how COVID-19 impacts cognition, neural function, and risk for Alzheimer’s may lead to new insights that inform clinically relevant future research on how age-related decline and dysfunction within the immune system may play a causal role in Alzheimer’s.
The award from the NIH’s National Institute on Aging for $643,396 is a supplement to Gluck’s current NIH grant, “Risk Factors for Future Cognitive Decline and Alzheimer’s Disease in Older African Americans,” and is in addition to another supplement the group will use to fund a minority postdoctoral fellowship. This brings their total 2021-2022 annual award from NIH for this project to $1,432,216.
Gluck and his lab will collaborate with two leading immunologists at the Rutgers Biomedical and Health Sciences (RBHS)/NJ Medical School on this new grant, Patricia Fitzgerald-Bocarsly, Provost of NJMS/RBHS-Newark and Professor of Pathology, and Marila Gennaro, Professor of Medicine and Epidemiology. The joint award will support interdisciplinary research across the three labs – bridging neuroscience, public health, and immunology – allowing graduate students and postdoctoral fellows from both Rutgers-Newark and RBHS to expand in new directions.
In describing the study, Gluck says “Our core goal is to answer the following question: What underlying immunological mechanism links both Alzheimer’s disease and COVID-19 to common risk factors and might thus explain causal (and possibly reciprocal) links between Alzheimer’s Disease and COVID-19 severity and mortality?”
There are numerous commonalities between Alzheimer’s Disease and COVID-19. Common risk factors for both include advanced age, hypertension, obesity, diabetes, and being African American. Older adults with Alzheimer’s, or healthy young individuals with Alzheimer’s Disease risk genes, are both at elevated risk for COVID-19 mortality. What is not known is whether the converse is also true: Will surviving COVID-19 increase future risk for Alzheimer’s Disease?
Both diseases are also known to damage the same area of the brain: the hippocampus, a key structure for encoding and storing new information. This brain region has been the focus of the Gluck Lab’s neurocomputational and cognitive neuroscience studies for the last three decades. What underlies these similarities between Alzheimer’s Disease and COVID-19? Could immune dysfunction be the common link? Although there is increasing evidence that Alzheimer’s involves disruption to the immune system, researchers do not sufficiently understand how Alzheimer’s Disease pathology and risk are related to specific processes within the immune system.
African Americans continue to suffer from high rates of COVID-19 mortality: About 3.6 times as high as the rate for white Americans. Older African Americans are particularly vulnerable to severe health consequences if they are exposed to the SARS-CoV-2 virus. It is not known why some older African Americans suffer far worse outcomes from COVID-19 than others, or what are the long-term health consequences of COVID-19 for African Americans. The new study will address both knowledge gaps.
Over the coming year the lab will be recruiting older African Americans from the greater Newark area who survived COVID-19 to join our study, in the hopes to better understand the long-term consequences of COVID-19 on brain health, immunological health, and Alzheimer’s Disease. A key partner in this recruitment will be the lab’s newest clinical collaborator, Dr. Alexander Salerno, the leader of Salerno Medical Associates which has provided medical care to the Newark/East Orange communities since the 1950s. They also run a non-profit health education program, Urban Healthcare Initiative Program (UHIP), with whom the Gluck lab has partnered for several years. Their medical practice, across five local clinics, cares for about 20,000 local residents, including approximately 6,000 older African Americans— about half of whom had COVID-19 in the past year. As an early leader in the area’s response to COVID-19, they have administered COVID-19 tests to over 120,000 local residents.
A deeper understanding of the linkages between Alzheimer’s Disease and COVID-19 may result both in better treatments for long-term neurological consequences of COVID-19 as well as advances in the field of Alzheimer’s Disease and related dementias. In particular, the lab’s studies could lead to a better understanding of the relationship between immune dysfunction and Alzheimer’s Disease, which, in turn, could inform future immunologically-focused clinical interventions for Alzheimer’s.
Story originally appeared in Rutgers School of Arts and Sciences-Newark.
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Rutgers in the News: The Passing of Justice Ginsburg, Pandemic Recovery Forecasts, and the Digital Divide in Schools
For news consumers, Rutgers experts appear in the...
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No Longer a Death Sentence: Transforming Cancer Care and Prevention in Africa
Rutgers Global Health Institute initiative...
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Rutgers in the News: COVID-19 Trials, Opioid Dangers, and Cyberattacks
Questions springing from the coronavirus are...
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Rutgers in the News: Increased COVID-19 Testing, Sanitization Overkill, and Wage Theft
Addressing complex questions and others, Rutgers...
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$5 Million Gift from Rutgers Alumnus Will Advance Fight against Alzheimer’s and Dementia
Herbert C. Klein, a Rutgers alumnus and longtime...
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Rutgers in the News: Back-to-School Challenges, Voter Ambivalence, and Cancer Treatment Despite COVID-19
As the new academic year begins, Rutgers students...
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Rutgers Develops Fast Way to Decontaminate N95 Masks
Two Rutgers-led studies have identified a more...
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New Jersey Maintains Economic Momentum, Defying National Trend
According to a new Rutgers report, New Jersey's...
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Rutgers in the News: Helpful Bacteria, Mail-In Ballots, and 19th Amendment Irony
Scores of Rutgers experts appear in the media...
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Rutgers in the News: Kamala Harris, Voting Controversies, and School Openings
Whether you’re looking for insight into U.S....
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Rutgers Researchers Awarded $20 Million NIH Grant to Find New Ways to Diagnose Tuberculosis
The research team of infectious disease experts...
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Early Antibiotic Use Increases Risk of Inflammatory Bowel Disease
A study, published in Genome Medicine, provides...
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Rutgers in the News: COVID-19 and the National Conversation on the Use of Power
Rutgers continues to serve as a model for...
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Greg and Anna Brown Commit $1 Million to Student Financial Aid
The gift from the Browns is the third...
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A Rutgers Giving Day Like No Other
Building on the momentum of previous years,...
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Alumni Gary and Barbara Rodkin Commit $1 Million to Student Financial Aid
The gift from Gary and Barbara Rodkin is the...
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Rutgers in the News: Educational Values, COVID-19, and the Economy
Rutgers continues to serve as a model for...
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Rutgers in the News: Social Justice and Navigating COVID
In these turbulent times, Rutgers continues to...
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Does Asthma Raise COVID Risks? New Rutgers Study Suggests No
Reynold A. Panettieri Jr., a pulmonary critical...
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Rutgers in the News: Addressing systemic injustice and opening schools in the face of COVID
News outlets turn to Rutgers faculty and...
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Rutgers Bacteria Study Could Lead to Better COVID Disinfection Methods
A new Rutgers study, published in the...
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Rutgers University Announces Fall 2020 Plans
The fall semester at Rutgers University will...
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Rutgers Board Chair Joins President Holloway’s Call to Action
Scarlet Promise Grants offer essential financial...
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Rutgers Experts on COVID Concerns, Equal Representation, and the Legacy of Racism
New Rutgers President Jonathan Holloway arrives...
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A message from Rutgers President Jonathan Holloway
Today, Jonathan Holloway, the 21st president of...
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Thank You For Your Support
Donors to Rutgers are exemplary. Many demonstrate...
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Impact Stories
Rutgers Experts on Containing COVID-19 and Fighting for Equality
As the rise in COVID cases complicates the...
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Rutgers Experts on Black Inequality and Coronavirus Safety
Your weekly guide to Rutgers experts in the news....
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Rutgers to Support Statewide Contact Tracing Program
Rutgers University has partnered with the State...
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Rutgers Experts on Racial Justice, COVID Pandemic, and New Political Realities
Members of the Rutgers community have come...
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The Perfect Storm of Pandemics
Brian L. Strom, chancellor of Rutgers Biomedical...
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Rutgers Sociologist Awarded Fellowship Aimed at Eradicating Racial Disparities in the Arts and Humanities
Melissa Valle is one of 32 fellows chosen from...
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Rutgers Researchers Receive Award to Develop First-in-Class Anticancer Therapeutics
Rutgers cancer researchers have been awarded...
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Charitable Gift Annuity Rates
The charitable gift annuity (CGA) is a simple and...
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Rutgers’ Critical Role in Pandemic Recovery
As areas of the country slowly reopen under...
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As the Nation Slowly Reopens, Rutgers Helps Chart the Path
University experts have been at the forefront of...
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How Rutgers Leads at a Time of Crisis
Rutgers University presence at the front lines of...
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New RWJMS Study Finds Young People at Greater Risk From COVID-19 Than Previously Thought
Children, teens and young adults are at greater...
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Rutgers Community is Responding to COVID-19
During these unprecedented times, Rutgers...
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FDA Approves First At-Home Saliva Collection Test for Coronavirus
Rutgers’ RUCDR Infinite Biologics received an...
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Rutgers Leads Clinical Trial of Drug to Prevent Cytokine Storms in COVID-19 Patients
Rutgers has launched a clinical trial to test...
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Rutgers Community Raises over $250,000 on #GivingTuesdayNow
Alumni and donors raise more than $250,000 for...
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Impact Stories
#GivingTuesdayNow: Join Rutgers in the Fight Against COVID-19
Join the global movement to fight COVID-19 today,...
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Rutgers Plays Key Role in Reopening New Jersey
Governor Phil Murphy's plan to safely rollback...
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Rutgers Law Mortgage Foreclosure Project Assists in Saving New Jersey Residents from Losing their Homes
A Rutgers University–Camden law professor and...
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Rutgers, University Hospital Lead Way in Treating COVID-19 with Convalescent Plasma from Recovered Patients
Rutgers physicians and University Hospital are...
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Rapid Screening Process for Infectious Diseases Being Created in Rutgers University–Camden Research Lab
The fight against the coronavirus is underway in...
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New Rutgers Saliva Test for Coronavirus Gets FDA Approval
The FDA has granted emergency use authorization...
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How the CARES Act Affects Charitable Giving
On March 27, in response to the economic strain...
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Message from President Barchi
Rutgers President Robert Barchi sends a message...
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Rutgers Launches Genetic Testing Service for New Coronavirus
Rutgers’ RUCDR Infinite Biologics has launched...
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What it Takes to Beat a Worldwide Pandemic
Rutgers Biomedical and Health Sciences (RBHS) has...
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Rutgers Creates COVID-19 Center to Fight Pandemic
Rutgers has created a new center to coordinate...
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New Device Quickly Detects Harmful Bacteria in Blood
Engineers have created a tiny device that can...
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How the Building Blocks of Life Got Built
Rutgers researchers have discovered the origins...
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Message to Alumni and Donors Regarding COVID-19 Response
Rutgers University Foundation president, Nevin...
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Supporting students during the COVID-19 outbreak
Many of you have asked how you can help students...
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Rutgers Recognized as a Leader in Supporting Low-Income Students
Rutgers University-New Brunswick is a national...
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Rutgers Leads $1.5 Million Project for Ocean Acidification Monitoring on the U.S. Northeast Shelf
Grace Saba, assistant professor, is the lead...
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Surgeon who Separated Conjoined Twins Mentors Rutgers Undergraduates
A Rutgers graduate, Stylianos led the teams that...
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Jonathan Holloway Named 21st President of Rutgers, The State University of New Jersey
Holloway will begin serving as president on July...
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Rutgers Giving Tuesday Initiative to End Student Hunger
Being a student is hard. It’s even harder when...
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Putting an End to a Pernicious Disease
Rutgers neuroscientists are exploring promising...
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Putting the Promise in Scarlet Promise Grants
In an effort to help more students avoid...
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Growing for the Greater Good
Through the generosity of donors such as Richard...
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Grand Opening Held for RWJBarnabas Health Athletic Performance Center at Rutgers University
Rutgers Athletics held a ribbon-cutting ceremony...
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Donor Profiles
Rutgers Alumnus Makes Largest Scholarship Gift Ever to University
Richard N. Weeks, a 1950 Rutgers graduate who...
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Foundation News
Rutgers’ Record-Breaking Fundraising Year Will Improve Lives in New Jersey and Beyond
Rutgers donors committed a record-breaking $250.9...
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Impact Stories
Rutgers Community Donates Paul Robeson Plaza
Rutgers is in the midst of celebrating 2019 as...
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Foundation News
Lavelle Fund Gift for Blindness Program
A grant from the Lavelle Fund for the Blind to...
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Donor Profiles
From Meter Reader to Multimillion-Dollar Donor: The Remarkable Journey of a SMLR Alumnus
Bill and Lois Dwyer are gifting $50,000 to...
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Impact Stories
Alumna Marlene Brandt commits $30 million to transform behavioral health care for young people
Spurred by a pressing need for comprehensive...
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Helping Tomorrow’s Leaders Meet Their Potential
Former Rutgers Assistance Grants get a boost with...
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Impact Stories
Prudential Establishes Newark Scholarship Program
Rutgers University–Newark received welcome news...
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Foundation News
The Demand for Special Needs Dentists
John Barnosky became an advocate for expanding...
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Rutgers Approves Construction of Athletic Practice Facility
The Rutgers University Board of Governors today...
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